Friday, October 31, 2025

DH25021 Learning from biology - Whales Long Life. V01 011125

 The whale that may hold secret of far longer life


Rhys Blakely - Science Editor

Humans spend fortunes on lotions, supplements and fads that promise to slow aging. The bowhead whale, a giant denizen of Arctic waters, has no such anxieties. It lives for centuries, rarely succumbing to cancer or other ailments that cut our lives short.

How does such a massive creature — weighing some 80 tonnes, with billions upon billions of cells — stay healthy for so long? Could its biology offer humans clues on how to defy age itself? Scientists at the University of Rochester in New York think so. In a study published in Nature, they have identified a protein known as CIRBP that appears to play a key role in prolonging the whale’s life. The molecule — short for “cold-inducible RNA-binding protein” — helps repair damaged DNA, a defence that fends off cancer.

When the researchers added the whale version of CIRBP to human cells, they repaired broken DNA more accurately.

In fruit flies, it even extended their lives.

Professor Vera Gorbunova, who led the study, believes the results could point to a treatment that allows future generations “to live longer than the typical human lifespan”.

With some bowhead whales believed to be at least 250 years old, the species is the longest-lived mammal.

“It’s a superstar of longevity research,” said Dr Alex Cagan, an evolutionary geneticist at the Wellcome Sanger Institute in the UK.

By studying the mammals, scientists hope to untangle a biological puzzle known as Peto’s paradox. Big animals, such as whales, should face higher cancer risks than small ones — simply because they have more cells dividing over longer lifespans. For some reason, or combination of reasons, they do not.

The study found that CIRBP helped to fix the most perilous form of genetic damage, so-called double-strand breaks to the DNA double helix — the structure inside the cell that carries genetic information. Bowhead whale cells perform these repairs both more efficiently and more accurately than those of humans or mice. As a result, its DNA stays pristine for an unusually long time.

Cagan said the findings were “intriguing” and pointed “towards new therapeutic angles that could be explored”.

The clue to why the whales have so much CIRBP may lie in their very cold Arctic habitat. Production of the protein rises when temperatures fall. “If we just lower the temperature a few degrees, cells make more CIRBP,” Andrei Seluanov, a co-author of the study, said.

That detail has sparked speculation.

Scientists were already asking whether mild exposure to chilly temperatures could help protect humans from disease.

If it does, could the human version of CIRBP play a role? “Lifestyle changes — things like taking cold showers — might contribute and might be worth exploring,” Gorbunova said.

Her team’s next steps will include testing whether CIRBP — or drugs that activate its production — reliably and safely improves DNA repair in smaller, shorter-lived mammals.

Tuesday, October 28, 2025

DH25020 Living Machinery by A.V.Hill V01 281025

 Nice question — A. V. Hill’s 1926 Christmas Lectures are a neat piece of science-communication history. Here’s a concise rundown with sources so you can read more.


What they were

In December 1926 Archibald Vivian (A. V.) Hill (Nobel laureate 1922) gave a series of six Royal Institution Christmas Lectures aimed at a “juvenile auditory.” The lecture series was published soon after under the title Living Machinery: Six Lectures (published 1927). 


Subject and flavour

Hill used the series to explain how our bodies work — especially nerves and muscles — in plain language for young people. He covered nerves, muscles, the heart, lungs and blood, and topics such as speed, strength and endurance, often illustrated by experiments involving his children (his daughter Janet took part) and even the family dog. The published lectures carry the informal, demonstrative style typical of the Ri Christmas Lectures. 


Why it mattered

Hill was already a prominent physiologist (shared the 1922 Nobel Prize for work on heat and mechanical work in muscle). These lectures helped translate contemporary muscle/nerve physiology to a general audience and fed into his later popular/scientific books (e.g. Muscular Activity, Muscular Movement in Man). They’re an early example of a Nobel-winning scientist doing public outreach in the Ri tradition. 


Where to read/watch

The lectures were printed as the book Living Machinery (1927) — you can find bibliographic entries and digitized copies referenced on Google Books and in library catalogues. For a modern discussion and context, see the open-access review on Hill’s legacy (which summarizes the Ri lectures and their contents). If you want the Ri’s archival help locating original programmes or photos, the Royal Institution archives can be contacted via their website. 


Quick pointers if you want more

Read the Living Machinery text (1927) for Hill’s original wording and demonstrations. (Google Books / academic libraries often have scans.) 

The PMC review article summarizes the lectures’ content and places them in Hill’s career — handy if you want scholarly context. 

The Royal Institution pages give background on the Christmas Lecture series itself and how to access their archive. 


If you’d like, I can:

pull the book’s table of contents and short excerpts (if available online) and paste them here, or

look up contemporary reviews (e.g. Nature, 1928) and include relevant excerpts and dates.


Which of those would be most helpful?

Saturday, October 18, 2025

DH25019 DNA the Informational Design Layer V01 181025

 AI question 


Is the whole of the living world dependant on an informational design of the living world layer with it’s only encoded standard DNA or is there another encoding standard. 


Answer


That’s a profound and important question — you’re essentially asking whether all life on Earth is built on one universal “information code” (DNA), or whether other informational systems exist (or could exist) that also encode living processes. Let’s unpack this carefully.


🧬 1. The universal encoding standard of life on Earth


All known life on Earth — from bacteria to humans — uses the same fundamental information system:

DNA (deoxyribonucleic acid) as the long-term information storage medium.

RNA (ribonucleic acid) as the messenger and sometimes catalyst.

Proteins as the main functional molecules.


This is often called “the central dogma” of molecular biology:

→ DNA → RNA → Protein


The “code” — the genetic code — translates sequences of 3 DNA bases (codons) into amino acids. What’s remarkable is that this code is almost universal across all known organisms. There are minor variations in a few species and organelles (like mitochondria), but the core mapping is the same everywhere.


So, yes — the living world as we know it shares a single informational design layer.


🧩 2. Could there be another encoding standard?


Yes — in principle. Biologists have explored and even constructed alternative systems:


a. Artificial or synthetic life


Researchers have created XNA (xeno nucleic acids), which use different sugar backbones or base pairs instead of the canonical A, T, G, and C.

XNAs can store information and even evolve.

They suggest that other encoding systems are physically possible, though none occur naturally on Earth (as far as we know).


b. Alternative genetic codes


A few organisms use modified codon–amino acid mappings (e.g., UGA coding for tryptophan in some mitochondria).

These are variations, not new systems — the fundamental design is still DNA-based.


c. Hypothetical alien life


If life exists elsewhere, it might use:

Different base molecules (not DNA/RNA).

Different coding logic (not triplet codons).

Even non-chemical information substrates (e.g., crystal lattices, quantum information, or metabolic networks).


So, other encoding standards could exist in theory, but we haven’t observed any beyond DNA/RNA-based life.


⚙️ 3. Informational design as a “layer”


You’re thinking in a systems-theoretic way — that the biosphere has an informational layer underlying its physical forms. That’s accurate:

The informational design (DNA sequences, regulatory logic, signaling codes) defines the behavior and structure of the biochemical layer.

This design is encoded in a standardized digital language — the genetic code — which gives biology its interoperability and evolutionary continuity.


In that sense, life is an information architecture realized in chemistry.


🧠 Summary


Concept Reality on Earth Possibility Beyond Earth

Encoding medium DNA (and RNA) XNA, other molecules

Information logic Genetic code (triplet codons → amino acids) Alternative mappings or entirely new logic

Universality Shared by all known life Could differ elsewhere

Informational design layer Real and universal in biosphere Theoretically generalizable


Would you like me to illustrate this with a layered model of the living world’s information architecture — showing the physical, chemical, and informational levels and how DNA serves as the design layer


Yes


Excellent — let’s build that model clearly.

Below is a conceptual “layered architecture of life” — showing how the living world can be understood as a hierarchy of information and matter, with DNA as the core informational design layer.


🧬 Layered Model of the Living World’s Information Architecture


1️⃣ Physical–Chemical Layer (Energy & Matter)


Nature: Raw physical substrate — atoms, molecules, and energy flows.

Components:

Carbon, hydrogen, oxygen, nitrogen, phosphorus, sulfur

Water, minerals, sunlight, and thermodynamic gradients


Function:

Provides the building blocks and energy that make life possible.

Follows purely physical and chemical laws (quantum, thermodynamic, etc.).


➡️ Analogy: The “hardware” on which life runs.


2️⃣ Biochemical Process Layer (Dynamic Chemistry)


Nature: Organized chemical networks.

Components:

Enzymes, metabolic pathways, membranes

Cellular machinery that executes reactions


Function:

Converts energy and materials into usable biological forms.

Enables growth, repair, and reproduction.


➡️ Analogy: The “operating system” that interprets and runs instructions.


3️⃣ Informational Design Layer (Genetic Encoding)


Nature: Digital information stored in molecular form.

Components:

DNA as long-term data storage

RNA as temporary messenger and functional molecule

Genetic code translating information into proteins


Function:

Encodes design blueprints for proteins and regulatory systems.

Serves as the informational standard for all known life.

Ensures reproducibility, inheritance, and evolution.


➡️ Analogy: The “software” — digital code specifying biological form and function.


4️⃣ Developmental & Functional Layer (Biological Expression)


Nature: Expression of encoded information into physical forms and functions.

Components:

Cells, tissues, organs, and whole organisms

Regulatory networks controlling gene expression


Function:

Executes the genetic program in context.

Allows adaptation, feedback, and environmental response.


➡️ Analogy: The “compiled application” — the living organism in action.


5️⃣ Ecological & Evolutionary Layer (Adaptive Network)


Nature: Interconnected web of living systems over time.

Components:

Ecosystems, species interactions, evolutionary dynamics


Function:

Enables life to evolve, adapt, and self-organize on a planetary scale.

The genetic information layer evolves through mutation, recombination, and selection.


➡️ Analogy: The “network” — a distributed adaptive system refining its code over billions of years.


Summary Diagram (Text Representation)


🌍 5. Ecological & Evolutionary Layer ─── Adaptive networks of life

🧠 4. Developmental & Functional Layer ─── Expression of encoded design

💾 3. Informational Design Layer ───────── DNA/RNA genetic code

⚗️ 2. Biochemical Process Layer ───────── Metabolism and molecular machinery

⚛️ 1. Physical–Chemical Layer ─────────── Atomic and energetic substrate


🧩 Optional Extension — “Alternative Encoding Standards”


If we imagine other biospheres (on Earth or beyond), the Informational Design Layer could hypothetically use:

XNA (xeno nucleic acids) — synthetic or alternative nucleic polymers

Peptide nucleic acids (PNA) — peptide-based information storage

Quantum or crystalline information substrates (speculative)


But in every case, the layered structure — matter → chemistry → information → expression → evolution — would likely recur.

That architecture might be a universal principle of living systems, regardless of the physical encoding standard.


Would you like me to render this as a visual diagram (a labeled layered schematic, suitable for a presentation or paper)?